By Lindsay Grace Weber
The Center for Disease Control identifies skin cancer as both the most common, and the most preventable, type of cancer in the U.S. [1] Though most skin cancer prevention and awareness campaigns target individuals in higher risk groups—i.e. light skinned individuals who burn or freckle easily—people with darker skin are also at risk for developing skin cancer. Individuals with increased skin pigmentation, including African-American, Asian, Latino and Indigenous people, do have additional protection from the harmful UV rays of the sun that lead to skin cancer. Despite this added protection, skin cancer is associated with higher mortality and morbidity within these populations due to the atypical presentation of skin cancer in dark skin, and the subsequent misdiagnosis of skin cancer by medical professionals. [2] With the summer sun now out in full force, it is important that all individuals take precautions against skin cancer.
What is Skin Cancer?
There are three types of skin cancer—basal cell carcinomas (BCC), squamous cell carcinomas (SCC), and melanoma. BCC, the most common form of skin cancer, is highly curable if found early, though it is associated with a high mortality rate if left untreated. SCC is the second most common type, and is also highly curable if diagnosed at an early stage. SCC is more common than BCC in dark skin, comprising 66% of skin cancer cases in people of color, often developing from pre-existing scar tissue, burns, and chronic inflammatory skin conditions (such as sores, ulcerations). [3] SCC is often found on mucous membranes and lips, and if left untreated will spread to other areas of the body, making it much harder to treat.
The third and most dangerous type of skin cancer is melanoma. Though it is the least common form, melanoma is more dangerous than BCC and SCC due to its ability to spread quickly to other areas of the body. [4] Most cases of melanoma are caused by exposure to UV rays and sunlight, and presents either in situ (as a localized tumor on the outer layer of skin) or invasive (where the cancer cells have permeated the outer layer of skin and begun spreading to other areas of the body). Of the four categories of melanomas—acral lentiginous, superficial spreading, lentigo maligna, and nodular melanoma—the first three begin in situ and progress to an invasive stage, while nodular melanoma is invasive from the start.
Melanoma is the most deadly form of skin cancer in people of color, as it is often diagnosed in darker skin after it has progressed to an invasive stage. On darker skin it often presents in areas with little to no sun-exposure; thus, melanomas are often misdiagnosed as plantar warts (foots warts), tinea nigra palmaris (fungus of the palm), or talan noir (dark nail). [5] Many general healthcare providers have little experience recognizing melanomas on darker skin, which makes it important to educate yourself and your loved ones about skin cancer, and to seek the expertise of a dermatologist who is familiar with all forms of skin cancer.
Who is at Risk?
Skin cancer is most commonly diagnosed in individuals with lighter skin tone (less pigmentation), with a personal or family history of skin cancer, or with a history of one or more severe blistering sunburns before the age of 18. [6] BCC is most common in elderly individuals, while SCC is frequently linked to family history of the disease. [7] Individuals with discoid lupus or human papillomavirus (HPV) are also at a higher risk for developing BCC and SCC. [8] Higher risk for developing SCC includes pre-existing skin conditions, such as actinic keratosis, sctinic cheilitis, leukoplakia, and Bowen’s disease, as well as exposure to prolonged x-rays. [9]
According to the 2005 Center for Disease Control cancer rates, the skin cancer incidence rate (for all three types) amongst Indigenous peoples in the U.S. was 4.8 per 100,000 people, and the rate for melanoma was 4.1, with a 1.3 mortality rate. While these rates are relatively low compared to populations with lighter skin, the significant melanoma mortality rate in Indigenous communities points to late or misdiagnosis, impressing further the need to be vigilant and aware about the risks associated with skin cancer. [10] Though Indigenous people’s skin may not be as vulnerable to harmful UV rays and sunburn, and skin cancer is relatively rare in Indigenous communities, no one immune to developing skin cancer. Young children and Indigenous people with lighter skin are particularly at risk for skin cancers caused by prolonged sun exposure.
Other Risk Factors
In addition to sun exposure, family history, and disease-associated predisposition to skin cancers, there are other risk factors that disproportionately affect Indigenous communities, most notably environmental factors. BCC can form on non-sun exposed areas of the body as a result of contact with arsenic and exposure to radiation. Indigenous people in the Southwest U.S. are thus more at risk for BCC due to naturally occurring arsenic deposits in local water sources. [11] Additionally, Indigenous communities ‘downwind’ of major nuclear testing or storage sites in the Western U.S.—including parts of California, Nevada, Utah, New Mexico, Washington, and Idaho—are also at a higher risk for developing skin cancer due to prolonged exposure to radiation. Individuals who work jobs associated with radioactive materials, including uranium mining and mill work, are also at higher risk for developing BCC due to exposure. [12] Exposure to insecticides, herbicides, fungicides and seed treatments, arsenic and ethylene glycol has been shown to increase the risk of developing SCC as well. People working with or around these chemicals, most notably farm and automobile workers, should be cautious of abnormal areas on the skin and seek regular skin exams. [13]
Symptoms
The American Cancer Society recommends monthly self administered skin exams, in addition to regular screenings by a health professional—once a year for people over the age of 40, and every three years for people ages 20-40. [14] Information about free skin cancer screenings and instructions for self-examination can be found at the end of the article.
Symptoms of BCC and SCC are similar, and may be confused with psoriasis and eczema in people with dark skin. They include the following symptoms: